What is methylcobalamin good for

what is methylcobalamin good for


Oct 08, †Ј Methylcobalamin is used to treat vitamin B12 deficiency. Vitamin B12 is important for the brain and nerves, and for the production of red blood cells. Methylcobalamin is sometimes used in people with pernicious anemia, diabetes, and other conditions. Methylcobalamin may also be used for purposes not listed in this medication lovedatme.com class: Vitamins. Jan 21, †Ј Methylcobalamin is a form of vitamin B Vitamin B12 is important for the brain and nerves, and for the production of red blood cells. Methylcobalamin is used to treat vitamin B12 deficiency. This medicine is sometimes used in people with .

Medically reviewed by Drugs. Last updated on Nov 2, Methylcobalamin has been used as how to keep track of stock portfolio supplement in patients with vitamin B 12 deficiency and in those with diabetes and other neuropathies. Although use in dementia is advocated, aside from correcting deficiencies, clinical trials are limited. Clinical trials with specific dosage recommendations for methylcobalamin are lacking.

Dosage is based on recommended dosages for vitamin B Medicines considered to reduce the absorption of vitamin B 12 include alcohol, aminosalicylic acid, chloramphenicol, colchicine, metformin, neomycin, and proton pump inhibitors. Vitamin B 12 at dosages found in foods or from supplements is well tolerated. GI effects from methylcobalamin may include anorexia, diarrhea, headache, nausea, and vomiting.

Specific toxicological studies are lacking. Vitamin B 12 has a long history of safe use even at high dosages. At usual dosages, the cobalt and cyanide content are not considered to be toxicologically relevant. Vitamin B 12 is obtained from animal products eg, meat, fish, shellfish, poultry, eggs, milk, milk products. Tempeh, made from fermented soybeans, contains the beneficial bacteria responsible for producing vitamin B Commercial forms of methylcobalamin are produced in the laboratory through the conversion of cyanocobalamin.

Early empirical work on the structure and function of cobalamins as coenzymes was conducted using vitamin B 12 -dependent bacteria in the s. The discovery of liver as a treatment for pernicious anemia in the s led to the Nobel Prize in Medicine, and in Karl Folkers and Alexander Todd identified cobalamin as the active principle in liver. Methylcobalamin is the methyl form of cobalamin obtained from hydroxycobalamin, either by chemical manipulation in the laboratory or in the body as a natural process.

Cyano- and hydroxocobalamin are considered the storage what is a status on facebook transport forms what is methylcobalamin good for cobalamin, while methylcobalamin and deoxyadenosylcobalamin are the active forms involved in enzymatic reactions.

Methylcobalamin is involved specifically in the normal metabolism of folate and the consequent maintenance of normal what does the name journey mean serum levels. The 4 cobalamins collectively are often referred to as vitamin B 12and are essential cofactors in the bone marrow and myeloid cells where the replication of chromosomes and cellular division occurs.

A lack of stomach acid occurs in elderly patients and among people taking proton pump inhibitors, leading to poor digestion of the vitamin from animal products. People with a lack of intrinsic factor also known as pernicious anemiaas well as those with severe GI disorders with impaired small intestine function eg, Crohn disease or those who have undergone gastric bypass surgery may also be deficient in vitamin B The deficiency can lead to subtle cognitive and neurologic changes, as well as to more severe anemia and dementia.

Vitamin B 12 deficiency can be corrected with the administration of cobalamin. Usually either cyano- or hydroxocobalamin is used to restore normal levels. Clinical trials specifically evaluating methylcobalamin supplementation are lacking.

However, there is no reason to suggest lack of efficacy, and reports exist of therapeutic efficacy of methylcobalamin. Limited clinical trials have evaluated the effect of supplemental methylcobalamin on diabetic peripheral neuropathy, as well as neuropathy associated with renal disease.

Subjective measures were reported to have improved. Reversal of moderate cognitive impairment dementia with oral methylcobalamin, but not hydroxocobalamin, was reported in an year-old female despite B 12 levels being within normal limits. Two months later, her Mini Mental State Examination improved from 14 to 29 and her body mass index improved from The American Academy of Neurology AAN updated practice guideline for mild cognitive impairment states that insufficient evidence is available to support or refute the use of homocysteine-lowering B vitamins, including vitamin B 12in patients with mild cognitive impairment Very Low Level, Class II.

Animal studies and clinical data suggest a role for what does a finger prick blood test show B 12 parenteral therapy in the care of the critically ill, especially in what is methylcobalamin good for however, clinical trials are lacking and information specifically regarding methylcobalamin is lacking.

A systematic review showed little evidence supporting vitamin B 12 supplementation to reduce the risk of diabetes or cardiovascular disease. Limited information suggests methylcobalamin may play a role in immune modulation and in cancer. Methylcobalamin has been used in clinical studies to reduce serum homocysteine levels.

No statistically significant difference was observed in sperm parameters compared to placebo. The DRI of vitamin B 12 is 2. Methylcobalamin 1, mcg IM 3 times what is methylcobalamin good for week for 2 weeks followed by weekly doses was reported to reverse neuropsychiatric symptoms in 1 what is methylcobalamin good for study. Clinical trials evaluating the effect of methylcobalamin how to use bit torent com to download movies diabetic neuropathy have used dosages of saline 2, micrograms in 10 mL injected intrathecally 10 and oral methylcobalamin mcg taken 3 times a day.

Methylcobalamin is at least as bioavailable as cyano- and hydroxycobalamin. In pregnant women the recommended intake of vitamin B 12 increases to 2. Supplementation with methylcobalamin may improve the nutritional status of pregnant women but data from clinical trials is lacking.

Information on interactions caused by methylcobalamin supplementation is lacking. Certain medicines are considered to reduce the absorption of vitamin B 12 including alcohol, aminosalicylic acid, chloramphenicol, colchicine, metformin, neomycin, and proton pump inhibitors.

Most antibiotics, methotrexate, or pyrimethamine invalidate folic acid and vitamin B 12 diagnostic blood assays. Vitamin B 12 at dosages found in foods, or from supplements is well tolerated. Headache has been reported. Vitamin B 12 as cyanocobalamin or hydroxocobalamin has a long history of safe use even at high doses cyanocobalamin 1 mg IM at weekly intervals for 1 month, followed by monthly injections for 6 months.

At usual doses, the cobalt and cyanide content are not considered to be toxicologically relevant. A what is methylcobalamin good for conducted in rats in the s suggested vitamin B 12 might exert tumor-promoting effects, while another study suggested reduced survival rates among rats with Walker carcinosarcoma treated with methyl- and cyanocobalamin.

This information relates to what is methylcobalamin good for herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA what is methylcobalamin good for determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This information should not be used to decide whether or not to take this product.

This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this product. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product.

This information is not specific medical advice and does not replace information you receive from your health care provider. You should talk with your health care provider for complete information about the risks and benefits of using this product.

This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. This product may be unsafe when used before surgery or other medical procedures.

It is important to fully inform your doctor about the herbal, vitamins, how to get admitted to federal court or any other supplements you are taking before any kind of surgery or medical procedure. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Methylcobalamin Medically reviewed by Drugs. Contraindications None identified. Interactions Medicines considered to reduce the absorption of vitamin B 12 include alcohol, aminosalicylic acid, chloramphenicol, colchicine, metformin, neomycin, and proton pump inhibitors. Adverse Reactions Vitamin B 12 at dosages found in foods or from supplements is well tolerated.

Toxicology Specific toxicological studies are lacking. Source Vitamin B 12 is obtained from animal products eg, meat, fish, shellfish, what is methylcobalamin good for, eggs, milk, milk products.

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Methyl B12 For Detoxification

Methylcobalamin is a critical supplement for those with MTHFR Gene Mutations, which makes them unable to detoxify well. Methylcobalamin B12 has been shown to be effective in helping the body to get rid of different kinds of toxins including: Mercury; Arsenic; Mycotoxins from mold; Glutamine (like from MSG and Aspartame). Aug 17, †Ј Methylcobalamin has long been known as the bodyТs essential Уbrain and energy vitamin.Ф Some even call it the УthinkerТs vitamin.Ф ThatТs because methylcobalamin is a special co-enzyme form of vitamin B thatТs natureТs most neurologically active form. ItТs also the most cerebrally invigorating form of B, because itТs the only form that can quickly and. Both methylcobalamin and cyanocobalamin can treat vitamin B12 deficiency. Animal and human studies have found that they could reduce symptoms of diabetic neuropathy and may have neuroprotective.

Japanese scientists have identified a form of vitamin B that protects against neurological disease and aging by a unique mechanism that differs from current therapies. Americans have immediate access to this unique and new form of vitamin B, and, unlike prescription drugs, it costs very little and is free of side effects.

Vitamin B is a general label for a group of essential biological compounds knows as cobalamins. The cobalamins are structurally related to hemoglobin in the blood, and a deficiency of vitamin B can cause anemia. The primary concern of conventional doctors is to maintain adequate cobalamin status to protect against anemia.

The most common form of vitamin B12 is called cyanocobalamin. However, over the last ten years, a number of central and peripheral neurological diseases have been linked to a deficiency of a very specific cobalamin, the methylcobalamin form, that is required to protect against neurological diseases and aging. The liver converts a small amount of cyanocobalamin into methylcobalamin within the body, but larger amounts of methylcobalamin are necessary to correct neurological defects and protect against aging.

Published studies show that high doses of methylcobalamin are needed to regenerate neurons as well as the myelin sheath that protects nerve axons and peripheral nerves.

On the other hand, vitamin B levels in the blood did not significantly deviate from normal ranges. According to Dr. Recent studies in Europe suggest that it needs to be given in large doses in the range of 10 Ч 20 mg per day, or even more. This supplementation of methylcobalamin might protect the cognitive function of patients with CFIDS by preventing the death of brain cells.

One cause of brain cell death is glutamate toxicity. Brain cells use glutamate as a neurotransmitter, but unfortunately glutamate is a double-edged sword in that it can also kill brain cells. The release of glutamate from the synapses is a usual means by which neurons communicate with each other.

Effective communication means controlled release of glutamate at the right time to the right cells, but when glutamate is released in excessive amounts, intercellular communication ceases. The flood of glutamate into the receiving neurons drives them into hyperactivity, and the excessive activity leads to cellular degradation. The good news is that it may now be possible to protect brain cells against glutamate toxicity by taking methylcobalamin supplementation.

In a study in the European Journal of Pharmacology , it was shown that methylcobalamin protected against glutamate-, aspartate- and nitroprusside- induced neurotoxicity in rat cortical neurons. Researchers concluded that methylcobalamin protects against neurotoxicity by enhancing brain cell methylation. The scientists who conducted the methylcobalamin studies emphasize that ongoing intake of methylcobalamin is necessary to protect against neurotoxicity.

Thus for methylcobalamin to be effective in protecting against neurological disease, daily supplementation may be required. An appropriate dose to protect against neurological aging might be 1 to 5 mg a day taken under the tongue in lozenge form.

Sleep A recent German study appearing in Neuropharmacology showed methylcobalamin reduced the amount of time subjects slept; sleep quality was better and subjects awoke feeling refreshed, with better alertness and concentration.

Part of this effect was apparently due to melatonin suppression during the daytime because morning methylcobalamin supplementation reduces drowsiness by decreasing daytime melatonin levels. A study in the Journal of Internal Medicine investigated the daily administration of 60 mg of methylcobalamin to patients with chronic progressive multiple sclerosis MS , a disease that has a poor prognosis and feature side spread demyelination in the central nervous system.

Although motor disability did not improve, there were clinical improvements in visual and auditory MS related disabilities. The scientist stated that methylcobalamin might be an effective adjunct to immunosuppressive treatment for chronic, progressive MS. Those with less serious forms of MS may consider adding methylcobalamin to their daily treatment regimen.

The effects of methylcobalamin were studied on an animal model of muscular dystrophy. This study, published in Neuroscience Letter looked at degeneration of axon motor terminals. In mice receiving methylcobalamin, nerve sprouts were more frequently observed and regeneration of motor nerve terminals occurred in sites that had been previously degenerating.

Regenerating Nerves Few substances have been shown to regenerate nerves in humans with peripheral neuropathies. However, a study in the Journal of Neurological Science postulated that methylcobalamin could increase protein synthesis and help regenerate nerves. The scientists showed that very high doses of methylcobalamin produce nerve regeneration in laboratory rats.

The scientists stated that ultra-high doses of methylcobalamin might be of clinical use for patients with peripheral neuropathies. The human equivalent dose the scientists used is about 40 mg of sublingually administered methylcobalamin on a daily basis.

Those suffering from peripheral neuropathies often take alpha lipoic acid. Based on our new understanding of peripheral neuropathy, it may be prudent that anyone using alpha lipoic acid also take at least 5 mg a day of sublingually administered methylcobalamin to ensure that alpha lipoic acid will be bioavailable to the peripheral nerves.

The administration of methylcobalamin for seven days suppressed liver, lung and ascites tumor growth. Mice receiving methylcobalamin survived longer than control mice did.

In mice irradiated before tumor cell inoculation, methylcobalamin did not improve survival. The effects of methylcobalamin on human immune function was investigated in the Journal of Clinical Immunology. The study showed that methylcobalamin demonstrated remarkable T cell-enhancing effects when the T cells were exposed to certain antigens. The scientists also showed that methylcobalamin improved the activity of T helper cells. The scientists concluded that methylcobalamin could modulate lymphocyte function by augmenting regulatory T cell activities.

Americans need to know about this important natural therapy that could extend the healthy human life span. A search of the scientific literature reveals published studies on methylcobalamin. However, it would not be an exaggeration to say that virtually no doctors know of it or are recommending it. Methylcobalamin should be considered for the treatment of any neurological disease. The sublingual intake of methylcobalamin is an affordable and effective natural therapy, and has proven even safe when given in large doses.

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